Three embryonic tissue sources—the neural ectoderm, the surface ectoderm, and the
periocular mesenchyme—contribute to the formation of the mammalian eye. For this reason …

The development of the vertebrate eyes is a complex process starting from anterior-posterior
and dorso-ventral patterning of the anterior neural tube, resulting in the formation of the eye …

The mature, functional, and healthy eye is generated by the coordinated regulatory
interaction of numerous and diverse developing tissues. The neural retina of the eye must …

The vertebrate eye is composed of both surface ectodermal and neuroectodermal
derivatives that evaginate laterally from an epithelial anlage of the forming diencephalon …

Organogenesis of the eye is a multistep process that starts with the formation of optic
vesicles followed by invagination of the distal domain of the vesicles and the overlying lens …

Vertebrate eye development has been an excellent model system to investigate basic
concepts of developmental biology ranging from mechanisms of tissue induction to the …

The mature eye is a complex organ that develops through a highly organized process during
embryogenesis. Alterations in its genetic programming can lead to severe disorders that …

This chapter provides an overview of the early developmental origins of six ocular tissues:
the cornea, lens, ciliary body, iris, neural retina, and retina pigment epithelium. Many of …

We review the current knowledge of transcription factors in mammalian eye development.
The 14 transcription factors presently known to be required for eye formation are examined …

In developed countries, malformations of the eye are among the most common causes of
serious visual impairment in newborns. The identification of pathogenic mutations in …