In this review, we discuss the genetic etiologies of Alzheimer's disease (AD). Furthermore,
we review genetic links to protein signaling pathways as novel pharmacological targets to …

Alzheimer's disease (AD) is the most common form of senile dementia, characterized by the
presymptomatic deposition of β-amyloid plaques followed by neurofibrillary tangles. After …

Alzheimer's disease (AD) is a complex disorder of the central nervous system (CNS).
Molecular genetic research has provided a wealth of information regarding the genetic …

The genetic underpinnings of Alzheimer's disease (AD) remain largely elusive despite early
successes in identifying three genes that cause early-onset familial AD (those that encode …

Linkage studies, candidate gene and whole-genome association studies have resulted in a
tremendous amount of putative risk genes for Alzheimer's disease (AD). Yet, besides the …

The search for the genetic factors contributing to Alzheimer disease (AD) has evolved
tremendously throughout the years. It started from the discovery of fully penetrant mutations …

Family history is the second strongest risk factor for Alzheimer disease (AD) following
advanced age. Twin and family studies indicate that genetic factors are estimated to play a …

Alzheimer's disease (AD) is the most frequent cause of dementia in the elderly and
represents an important and increasing clinical challenge in terms of diagnosis and …

Abstract About 1% of Alzheimer's Disease (AD) cases have an early-onset autosomal
dominant familial form of the disease, genetic analyses of which have found three causal …

Alzheimer's disease (AD) is a genetically complex and heterogeneous disorder. Fully
penetrant (causal) mutations leading to predominantly early-onset familial AD have been …