Age-associated SARS-CoV-2 breakthrough infection and changes in immune response in a mouse model

Y Chen, C Li, F Liu, Z Ye, W Song… - Emerging Microbes & …, 2022 - Taylor & Francis
Older individuals are at higher risk of SARS-CoV-2 infection and severe outcomes, but the
underlying mechanisms are incompletely understood. In addition, how age modulates SARS …

Aging & COVID-19 susceptibility, disease severity, and clinical outcomes: The role of entangled risk factors

M Farshbafnadi, SK Zonouzi, M Sabahi… - Experimental …, 2021 - Elsevier
Abstract The emergence of Severe Acute Respiratory Syndrome Corona Virus 2 (SARS-CoV-
2) in late 2019 has been associated with a high rate of mortality and morbidity. It has been …

[HTML][HTML] Role of senescence in the chronic health consequences of COVID-19

EOW Gerdes, G Vanichkachorn, BP Verdoorn… - Translational …, 2022 - Elsevier
While the full impact of COVID-19 is not yet clear, early studies have indicated that upwards
of 10% of patients experience COVID-19 symptoms longer than 3 weeks, known as Long …

[HTML][HTML] Innate and adaptive immunity in aging and longevity: the foundation of resilience

A Moskalev, I Stambler, C Caruso - Aging and disease, 2020 - ncbi.nlm.nih.gov
The interrelation of the processes of immunity and senescence now receives an
unprecedented emphasis during the COVID-19 pandemic, which brings to the fore the …

How immunosenescence and inflammaging may contribute to hyperinflammatory syndrome in COVID-19

L Müller, S Di Benedetto - International journal of molecular sciences, 2021 - mdpi.com
Aging is characterized by the dynamic remodeling of the immune system designated
“immunosenescence,” and is associated with altered hematopoiesis, thymic involution, and …

SARS-CoV-2 and COVID-19 in older adults: what we may expect regarding pathogenesis, immune responses, and outcomes

J Nikolich-Zugich, KS Knox, CT Rios, B Natt… - Geroscience, 2020 - Springer
Abstract SARS-CoV-2 virus, the causative agent of the coronavirus infectious disease-19
(COVID-19), is taking the globe by storm, approaching 500,000 confirmed cases and over …

A public health perspective of aging: do hyper-inflammatory syndromes such as COVID-19, SARS, ARDS, cytokine storm syndrome, and post-ICU syndrome …

A Bektas, SH Schurman, C Franceschi, L Ferrucci - Immunity & Ageing, 2020 - Springer
A central clinical question as the world deals with the COVID-19 pandemic is what the long-
term sequelae for the millions of individuals will be who recover from the hyperinflammatory …

COVID-19 in the elderly people and advances in vaccination approaches

K Dhama, SK Patel, S Natesan, KS Vora… - Human vaccines & …, 2020 - Taylor & Francis
The rapid worldwide spread of the COVID-19 pandemic, caused by the newly emerged
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has resulted in tens of …

[HTML][HTML] Molecular and cellular immune features of aged patients with severe COVID-19 pneumonia

D Lo Tartaro, A Neroni, A Paolini, R Borella… - Communications …, 2022 - nature.com
Aging is a major risk factor for developing severe COVID-19, but few detailed data are
available concerning immunological changes after infection in aged individuals. Here we …

[HTML][HTML] COVID-19, virology and geroscience: a perspective

C Vellas, P Delobel, PDS Barreto, J Izopet - The journal of nutrition, health …, 2020 - Elsevier
A new coronavirus, called SARS-CoV-2, was identified in Wuhan, China, in December 2019.
The SARS-CoV-2 spread very rapidly, causing a global pandemic, Coronavirus Disease …