[HTML][HTML] Age-related susceptibility to coronavirus infections: role of impaired and dysregulated host immunity
R Channappanavar, S Perlman - The Journal of clinical …, 2020 - Am Soc Clin Investig
Human coronaviruses (hCoVs) cause severe respiratory illness in the elderly. Age-related
impairments in innate immunity and suboptimal virus-specific T cell and antibody responses …
impairments in innate immunity and suboptimal virus-specific T cell and antibody responses …
[HTML][HTML] Cellular senescence in lymphoid organs and immunosenescence
V Budamagunta, TC Foster, D Zhou - Aging (Albany NY), 2021 - ncbi.nlm.nih.gov
Immunosenescence is a multi-faceted phenomenon at the root of age-associated immune
dysfunction. It can lead to an array of pathological conditions, including but not limited to a …
dysfunction. It can lead to an array of pathological conditions, including but not limited to a …
[HTML][HTML] Virus-induced senescence is a driver and therapeutic target in COVID-19
S Lee, Y Yu, J Trimpert, F Benthani, M Mairhofer… - Nature, 2021 - nature.com
Derailed cytokine and immune cell networks account for the organ damage and the clinical
severity of COVID-19 (refs.,,–). Here we show that SARS-CoV-2, like other viruses, evokes …
severity of COVID-19 (refs.,,–). Here we show that SARS-CoV-2, like other viruses, evokes …
[HTML][HTML] COVID-19 and quarantine, a catalyst for ageism
N Barth, J Guyot, SA Fraser, M Lagacé… - Frontiers in public …, 2021 - frontiersin.org
In February 2021, France had more than 76,000 deaths due to COVID-19 and older adults
were heavily affected. Most measures taken to reduce the impact of COVID-19 (quarantine …
were heavily affected. Most measures taken to reduce the impact of COVID-19 (quarantine …
[HTML][HTML] Cytokine storm in aged people with CoV-2: possible role of vitamins as therapy or preventive strategy
Abstract Background In December 2019, a novel human-infecting coronavirus, SARS-CoV-
2, had emerged. The WHO has classified the epidemic as a “public health emergency of …
2, had emerged. The WHO has classified the epidemic as a “public health emergency of …
[HTML][HTML] Age and age-related diseases: role of inflammation triggers and cytokines
IM Rea, DS Gibson, V McGilligan… - Frontiers in …, 2018 - frontiersin.org
Cytokine dysregulation is believed to play a key role in the remodeling of the immune
system at older age, with evidence pointing to an inability to fine-control systemic …
system at older age, with evidence pointing to an inability to fine-control systemic …