Metformin as a geroprotector: experimental and clinical evidence

V Piskovatska, N Stefanyshyn, KB Storey… - Biogerontology, 2019 - Springer
Apart from being a safe, effective and globally affordable glucose-lowering agent for the
treatment of diabetes, metformin has earned much credit in recent years as a potential anti …

The use of metformin to increase the human healthspan

V Piskovatska, KB Storey, AM Vaiserman… - Reviews on New Drug …, 2020 - Springer
Metformin is a safe, effective and useful drug for glucose management in patients with
diabetes. However in recent years, more attention has been paid to the possibility of using …

Metformin: a hopeful promise in aging research

MG Novelle, A Ali, C Diéguez… - Cold Spring …, 2016 - perspectivesinmedicine.cshlp.org
Even though the inevitable process of aging by itself cannot be considered a disease, it is
directly linked to life span and is the driving force behind all age-related diseases. It is an …

Metformin as a geroprotector

S Bulterijs - Rejuvenation research, 2011 - liebertpub.com
Geroprotectors are drugs that decrease the rate of aging and therefore extend life span.
Metformin has been described as a geroprotector, and several studies have shown that …

Targeting ageing and preventing organ degeneration with metformin

AP Sunjaya, AF Sunjaya - Diabetes & Metabolism, 2021 - Elsevier
Background Ageing is characterized by a decline in cognitive and bodily functions.
Metformin, the most commonly prescribed antidiabetic agent today, has proved to be able to …

[HTML][HTML] Metformin in aging and aging-related diseases: clinical applications and relevant mechanisms

S Chen, D Gan, S Lin, Y Zhong, M Chen, X Zou… - Theranostics, 2022 - ncbi.nlm.nih.gov
Aging is a natural process, which plays a critical role in the pathogenesis of a variety of
diseases, ie, aging-related diseases, such as diabetes, osteoarthritis, Alzheimer disease …

Benefits of metformin in attenuating the hallmarks of aging

AS Kulkarni, S Gubbi, N Barzilai - Cell metabolism, 2020 - cell.com
Biological aging involves an interplay of conserved and targetable molecular mechanisms,
summarized as the hallmarks of aging. Metformin, a biguanide that combats age-related …

[HTML][HTML] Metformin's mechanisms in attenuating hallmarks of aging and age-related disease

FF Cheng, YL Liu, J Du, JT Lin - Aging and disease, 2022 - ncbi.nlm.nih.gov
Aging is a major global challenge, and there is growing demand for new strategies to
address the burden of aging. The intensive search for antiaging agents has led to the …

[HTML][HTML] A critical review of the evidence that metformin is a putative anti-aging drug that enhances healthspan and extends lifespan

I Mohammed, MD Hollenberg, H Ding… - Frontiers in …, 2021 - frontiersin.org
The numerous beneficial health outcomes associated with the use of metformin to treat
patients with type 2 diabetes (T2DM), together with data from pre-clinical studies in animals …

[HTML][HTML] Metformin: a potential candidate for targeting aging mechanisms

D Hu, F Xie, Y Xiao, C Lu, J Zhong, D Huang… - Aging and …, 2021 - ncbi.nlm.nih.gov
Aging is a universal phenomenon in all biological organisms, defined by the loss of
reproductive capacity and a progressive decline in fitness. In humans, aging is further …