Single-cell epigenomic landscape of peripheral immune cells reveals establishment of trained immunity in individuals convalescing from COVID-19
M You, L Chen, D Zhang, P Zhao, Z Chen, EQ Qin… - Nature cell …, 2021 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection often causes
severe complications and even death. However, asymptomatic infection has also been …
severe complications and even death. However, asymptomatic infection has also been …
Epigenetic landscapes of single-cell chromatin accessibility and transcriptomic immune profiles of T cells in COVID-19 patients
S Li, B Wu, Y Ling, M Guo, B Qin, X Ren… - Frontiers in …, 2021 - frontiersin.org
T cells play a critical role in coronavirus diseases. How they do so in COVID-19 may be
revealed by analyzing the epigenetic chromatin accessibility of cis-and trans-regulatory …
revealed by analyzing the epigenetic chromatin accessibility of cis-and trans-regulatory …
A single-cell atlas of lymphocyte adaptive immune repertoires and transcriptomes reveals age-related differences in convalescent COVID-19 patients
F Bieberich, R Vazquez-Lombardi… - Frontiers in …, 2021 - frontiersin.org
COVID-19 disease outcome is highly dependent on adaptive immunity from T and B
lymphocytes, which play a critical role in the control, clearance and long-term protection …
lymphocytes, which play a critical role in the control, clearance and long-term protection …
Multi-omic profiling reveals widespread dysregulation of innate immunity and hematopoiesis in COVID-19
Our understanding of protective versus pathological immune responses to SARS-CoV-2, the
virus that causes coronavirus disease 2019 (COVID-19), is limited by inadequate profiling of …
virus that causes coronavirus disease 2019 (COVID-19), is limited by inadequate profiling of …
Single-cell multi-omics analysis of the immune response in COVID-19
Abstract Analysis of human blood immune cells provides insights into the coordinated
response to viral infections such as severe acute respiratory syndrome coronavirus 2, which …
response to viral infections such as severe acute respiratory syndrome coronavirus 2, which …
Single-cell landscape of immunological responses in patients with COVID-19
Abstract In coronavirus disease 2019 (COVID-19), caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) infection, the relationship between disease severity …
syndrome coronavirus 2 (SARS-CoV-2) infection, the relationship between disease severity …
Integrating single-cell sequencing data with GWAS summary statistics reveals CD16+ monocytes and memory CD8+ T cells involved in severe COVID-19
Background Understanding the host genetic architecture and viral immunity contributes to
the development of effective vaccines and therapeutics for controlling the COVID-19 …
the development of effective vaccines and therapeutics for controlling the COVID-19 …
[HTML][HTML] COVID-19 immune features revealed by a large-scale single-cell transcriptome atlas
A dysfunctional immune response in coronavirus disease 2019 (COVID-19) patients is a
recurrent theme impacting symptoms and mortality, yet a detailed understanding of pertinent …
recurrent theme impacting symptoms and mortality, yet a detailed understanding of pertinent …
Integrated longitudinal immunophenotypic, transcriptional, and repertoire analyses delineate immune responses in patients with COVID-19
S Notarbartolo, V Ranzani, A Bandera, P Gruarin… - Science …, 2021 - science.org
To understand how a protective immune response against SARS-CoV-2 develops over time,
we integrated phenotypic, transcriptional, and repertoire analyses on PBMCs from patients …
we integrated phenotypic, transcriptional, and repertoire analyses on PBMCs from patients …
Multimodal single-cell datasets characterize antigen-specific CD8+ T cells across SARS-CoV-2 vaccination and infection
The immune response to SARS-CoV-2 antigen after infection or vaccination is defined by
the durable production of antibodies and T cells. Population-based monitoring typically …
the durable production of antibodies and T cells. Population-based monitoring typically …