Targeting cancer with mRNA–lipid nanoparticles: key considerations and future prospects

E Kon, N Ad-El, I Hazan-Halevy… - Nature reviews clinical …, 2023 - nature.com
Harnessing mRNA–lipid nanoparticles (LNPs) to treat patients with cancer has been an
ongoing research area that started before these versatile nanoparticles were successfully …

Lipid nanoparticle (LNP) enables mRNA delivery for cancer therapy

Y Zong, Y Lin, T Wei, Q Cheng - Advanced Materials, 2023 - Wiley Online Library
Messenger RNA (mRNA) has received great attention in the prevention and treatment of
various diseases due to the success of coronavirus disease 2019 (COVID‐19) mRNA …

[HTML][HTML] mRNA: A promising platform for cancer immunotherapy

B Kong, Y Kim, EH Kim, JS Suk, Y Yang - Advanced Drug Delivery Reviews, 2023 - Elsevier
Messenger RNA (mRNA) is now in the limelight as a powerful tool for treating various
human diseases, especially malignant tumors, thanks to the remarkable clinical outcomes of …

Lipid nanoparticle-based mRNA delivery systems for cancer immunotherapy

J Han, J Lim, CPJ Wang, JH Han, HE Shin, SN Kim… - Nano …, 2023 - Springer
Cancer immunotherapy, which harnesses the power of the immune system, has shown
immense promise in the fight against malignancies. Messenger RNA (mRNA) stands as a …

Advances in lipid nanoparticles for mRNA-based cancer immunotherapy

ML Guevara, F Persano, S Persano - Frontiers in chemistry, 2020 - frontiersin.org
Over the past decade, messenger RNA (mRNA) has emerged as potent and flexible platform
for the development of novel effective cancer immunotherapies. Advances in non-viral gene …

Lipid nanoparticle-based mRNA vaccines in cancers: Current advances and future prospects

T Huang, L Peng, Y Han, D Wang, X He… - Frontiers in …, 2022 - frontiersin.org
Messenger RNA (mRNA) vaccines constitute an emerging therapeutic method with the
advantages of high safety and efficiency as well as easy synthesis; thus, they have been …

Recent advancements in lipid–mRNA nanoparticles as a treatment option for cancer immunotherapy

P Karmacharya, BR Patil, JO Kim - Journal of pharmaceutical investigation, 2022 - Springer
Background Cancer remains a serious health concern worldwide, and different approaches
are being developed for its treatment. The strategy to use the immune system as an …

Personalized tumor RNA loaded lipid-nanoparticles prime the systemic and intratumoral milieu for response to cancer immunotherapy

EJ Sayour, A Grippin, G De Leon, B Stover… - Nano …, 2018 - ACS Publications
Translation of nanoparticles (NPs) into human clinical trials for patients with refractory
cancers has lagged due to unknown biologic reactivities of novel NP designs. To overcome …

Delivering the right message: Challenges and opportunities in lipid nanoparticles-mediated modified mRNA therapeutics—An innate immune system standpoint

Y Granot, D Peer - Seminars in immunology, 2017 - Elsevier
Abstract mRNA molecules hold tremendous potential as a tool for gene therapy of a wide
range of diseases. However, the main hurdle in implementation of mRNA for therapeutics …

Recent advances in site-specific lipid nanoparticles for mRNA delivery

X Xu, T Xia - ACS Nanoscience Au, 2023 - ACS Publications
The success of mRNA vaccines during the COVID-19 pandemic has greatly accelerated the
development of mRNA therapy. mRNA is a negatively charged nucleic acid that serves as a …