ACE2 expression is increased in the lungs of patients with comorbidities associated with severe COVID-19

BGG Pinto, AER Oliveira, Y Singh… - The Journal of …, 2020 - academic.oup.com
Patients who died from COVID-19 often had comorbidities, such as hypertension, diabetes,
and chronic obstructive lung disease. Although angiotensin-converting enzyme 2 (ACE2) is …

ACE2 expression in kidney and testis may cause kidney and testis infection in COVID-19 patients

C Fan, W Lu, K Li, Y Ding, J Wang - Frontiers in medicine, 2021 - frontiersin.org
In December 2019, a new type of pneumonia caused by SARS-Cov-2 (COVID-19) occurred
in Wuhan and has been discovered in many countries around the world. ACE2 (angiotensin …

Single-cell RNA-seq data analysis on the receptor ACE2 expression reveals the potential risk of different human organs vulnerable to 2019-nCoV infection

X Zou, K Chen, J Zou, P Han, J Hao, Z Han - Frontiers of medicine, 2020 - Springer
It has been known that, the novel coronavirus, 2019-nCoV, which is considered similar to
SARS-CoV, invades human cells via the receptor angiotensin converting enzyme II (ACE2) …

[PDF][PDF] Susceptibility analysis of COVID-19 in smokers based on ACE2

J Wang, Q Luo, R Chen, T Chen, J Li - 2020 - pdfs.semanticscholar.org
Background: Cigarette smoking (CS) is a global public health problem and a high-risk factor
for various diseases. In December 2019, a novel coronavirus (COVID-19) was identified in …

Smoking-mediated upregulation of the androgen pathway leads to increased SARS-CoV-2 susceptibility

J Chakladar, N Shende, WT Li, M Rajasekaran… - International journal of …, 2020 - mdpi.com
The COVID-19 pandemic is marked by a wide range of clinical disease courses, ranging
from asymptomatic to deadly. There have been many studies seeking to explore the …

Advances in research on ACE2 as a receptor for 2019-nCoV

J Wu, W Deng, S Li, X Yang - Cellular and Molecular Life Sciences, 2021 - Springer
Currently, a novel coronavirus (SARS-CoV-2, also called 2019-nCoV) has triggered
pandemic Coronavirus Disease 2019 (COVID-19), an acute infectious respiratory disease …

[HTML][HTML] Specific ACE2 expression in small intestinal enterocytes may cause gastrointestinal symptoms and injury after 2019-nCoV infection

H Zhang, HB Li, JR Lyu, XM Lei, W Li, G Wu… - International journal of …, 2020 - Elsevier
Abstract The coronavirus disease 2019 (COVID-19) was first reported in Wuhan, China and
rapidly spread in other countries in December 2019. The infected patients presented with …

In vitro and in vivo identification of clinically approved drugs that modify ACE2 expression

S Sinha, K Cheng, AA Schäffer, K Aldape… - Molecular systems …, 2020 - embopress.org
The COVID‐19 pandemic caused by SARS‐CoV‐2 has been a global health challenge.
Angiotensin‐converting enzyme 2 (ACE 2) is the host receptor for SARS‐CoV‐2 entry …

Bulk and single-cell transcriptomics identify tobacco-use disparity in lung gene expression of ACE2, the receptor of 2019-nCov

G Cai - MedRxiv, 2020 - medrxiv.org
In current severe global emergency situation of 2019-nCov outbreak, it is imperative to
identify vulnerable and susceptible groups for effective protection and care. Recently …

The impact of ACE2 polymorphisms on COVID-19 disease: susceptibility, severity, and therapy

F Chen, Y Zhang, X Li, W Li, X Liu… - Frontiers in Cellular and …, 2021 - frontiersin.org
The coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), has currently spread worldwide, leading to high morbidity and …