In this study we explored the association between aging-related phenotypes previously
reported to predict survival in old age and variation in 77 genes from the DNA repair …

Genetic factors contribute to human aging and longevity through the modulation of biologic
pathways, but few longevity-gene associations have been replicated to date. Participants in …

Recently we have shown that the human life span is influenced jointly by many common
single-nucleotide polymorphisms (SNPs), each with a small individual effect. Here we …

Genetic factors clearly contribute to exceptional longevity and healthy aging in humans, yet
the identification of the underlying genes remains a challenge. Longevity is a complex …

Here we explore association with human longevity of common genetic variation in three
major candidate pathways: GH/IGF-1/insulin signaling, DNA damage signaling and repair …

Given the rising rate of survival into advanced old age in the United States, achieving
longevity and healthy aging is becoming increasingly important. Besides maintaining …

Genetic studies have thus far identified a limited number of loci associated with human
longevity by applying age at death or survival up to advanced ages as phenotype. As an …

Although there is compelling evidence for a genetic contribution to longevity, identification of
specific genes that robustly associate with longevity has been a challenge. In order to …

By studying the loci that contribute to human longevity, we aim to identify mechanisms that
contribute to healthy aging. To identify such loci, we performed a genome‐wide association …

Background: Recent studies investigating longevity have revealed very few convincing
genetic associations with increased lifespan. This is, in part, due to the complexity of …