Caloric restriction, leanness and decreased activity of insulin/insulin‐like growth factor 1
(IGF‐1) receptor signaling are associated with increased longevity in a wide range of …

Caloric restriction and leanness have been shown to increase longevity in organisms
ranging from yeast to mammals. Adipose tissue seems to be a pivotal organ in the aging …

Caloric restriction has been shown to increase longevity in organisms ranging from yeast to
mammals. In some organisms, this has been associated with a decreased fat mass and …

Impaired insulin/IGF 1 signalling has been shown to extend lifespan in model organisms
ranging from yeast to mammals. Here we sought to determine the effect of targeted …

A hallmark of ageing is dysfunction in nutrient signalling pathways that regulate glucose
homeostasis, negatively affecting whole-body energy metabolism and ultimately increasing …

Mitochondrial biogenesis is essential for cell viability. Growth hormone receptor knockout
(GHRKO), calorie restriction, and surgical visceral fat removal constitute experimental …

Mitochondrial enzyme expression is reduced in adipose tissue from old mice, yet little is
known regarding mechanisms that could be mediating, or interventions that could be used …

Deregulation of mitochondrial dynamics leads to the accumulation of oxidative stress and
unhealthy mitochondria; consequently, this accumulation contributes to premature aging …

In this review, we discuss the genes and the related signal pathways that regulate aging and
longevity by reviewing recent findings of genetic longevity models in rodents in reference to …

Increasing evidence suggests that reduced adipose tissue mitochondrial content is
associated with the pathogenesis of type 2 diabetes. These investigations have utilized …