Older adults are more susceptible to viral and bacterial infection, and experience higher
incidence and severity of infectious diseases. Although vaccination is the most logical …

Aging is associated with declines in immune system function, or 'immunosenescence',
leading to progressive deterioration in both innate and adaptive immunity. These changes …

The age-related dysregulation and decline of the immune system—collectively termed
“immunosenescence”—has been generally associated with an increased susceptibility to …

Immunosenescence is a process associated with aging that leads to dysregulation of cells of
innate and adaptive immunity, which may become dysfunctional. Consequently, older adults …

Successful vaccination of the elderly against important infectious pathogens that cause high
morbidity and mortality represents a growing public health priority. Building on the theme of …

Vaccination remains the most effective prophylactic intervention for infectious disease in the
healthcare professional's toolkit. However, the efficacy and effectiveness of vaccines …

Average life expectancy is continuously rising in all developed countries, leading to an ever-
increasing elderly population. Of the many functions of the body affected by the complex …

The increased susceptibility of the elderly to infection presents a major challenge to public
health services. An aging immune system is well documented as the cause of increased …

The most profound consequences of immune senescence with respect to human health are
the increased susceptibility to infectious diseases and decreased vaccine efficacy. Changes …

The progressive increase of the aged population worldwide mandates new strategies to
ensure sustained health and well-being with age. The development of better and/or new …