Abstract The 4D Nucleome (4DN) Network aims to elucidate the complex structure and
organization of chromosomes in the nucleus and the impact of their disruption in disease …

Recent progress in whole-genome mapping and imaging technologies has enabled the
characterization of the spatial organization and folding of the genome in the nucleus. In …

The 4D organization of the interphase nucleus, or the 4D Nucleome (4DN), reflects a
dynamical interaction between 3D genome structure and function and its relationship to …

Recent methodological advancements in microscopy and DNA sequencing-based methods
provide unprecedented new insights into the spatio-temporal relationships between …

A multitude of sequencing-based and microscopy technologies provide the means to
unravel the relationship between the three-dimensional organization of genomes and key …

Current evidence suggests that the nucleus has a distinct substructure, albeit one that is
dynamic rather than a rigid framework. Viral infection, oncogene expression, and inherited …

Compartmentalization is a ubiquitous feature of cellular function. In the nucleus, early
observations revealed a non-random spatial organization of the genome with a large-scale …

The intrinsic dynamic nature of chromosomes is emerging as a fundamental component in
regulating DNA transcription, replication, and damage-repair among other nuclear functions …

Genomes are more than linear sequences. In vivo they exist as elaborate physical
structures, and their functional properties are strongly determined by their cellular …

The intricacies of the 3D hierarchical organization of the genome have been approached by
many creative modeling studies. The specific model/simulation technique combination …