DNA methylation is a highly regulated process that has a critical role in human development
and homeostatic control of the cell. The number of genes affected by anomalous DNA …

Aberrant DNA methylation in the genome is found in almost all types of cancer and
contributes to malignant transformation by silencing multiple tumour-suppressor genes …

DNA methylation is an important and reversible epigenetic modification, which regulates
genomic stability and cellular plasticity. Faithful DNA methylation is essential for mammalian …

DNA methylation is an epigenetic modification of the DNA sequence and thus does not
change the genetic code but affects chromosomal stability and gene expression. DNA …

Cancer initiation and proliferation is regulated by both epigenetic and genetic events with
epigenetic modifications being increasingly identified as important targets for cancer …

The malignant transformation of normal cells is driven by both genetic and epigenetic
changes. With the advent of next-generation sequencing and large-scale multinational …

Simple Summary Cancer is a distinctly difficult disease to treat on account of the diverse cell
populations/subpopulations that comprise a tumour. Such cells harbour varying genetic and …

Knowledge of epigenetic alterations in cancer is rapidly increasing due to the development
of genome-wide techniques for their identification. DNA methylation is the best understood …

Recent conceptual advances in the field of DNA methylation and the advent and rapid
development of new technologies in epigenomics have started to unravel the mechanisms …

Carcinogenesis is accompanied by widespread DNA methylation changes within the cell.
These changes are characterized by a globally hypomethylated genome with focal …