Interpretation of the function of non-coding risk loci for neuropsychiatric disorders and brain-
relevant traits via gene expression and alternative splicing quantitative trait locus (e/sQTL) …

Tissue-specific regulatory regions harbor substantial genetic risk for disease. Because brain
development is a critical epoch for neuropsychiatric disease susceptibility, we characterized …

Current evidence emerging from genome‐wide association studies indicates that the
genetic underpinnings of complex traits are likely attributable to genetic variation that …

Genome-wide association studies have generated an increasing number of common
genetic variants associated with neurological and psychiatric disease risk. An improved …

Common genetic risk for neuropsychiatric disorders is enriched in regulatory elements
active during cortical neurogenesis. However, it remains poorly understood as to how these …

Background Genetic influences on gene expression in the human fetal brain plausibly
impact upon a variety of postnatal brain-related traits, including susceptibility to …

Methods integrating genetics with transcriptomic reference panels prioritize risk genes and
mechanisms at only a fraction of trait-associated genetic loci, due in part to an overreliance …

To date, most expression quantitative trait loci (eQTL) studies, which investigate how genetic
variants contribute to gene expression, have been performed in heterogeneous brain …

Neuropsychiatric genome-wide association studies (GWASs), including those for autism
spectrum disorder and schizophrenia, show strong enrichment for regulatory elements in the …

Single-cell technologies enable measure of unique cellular signatures, but are typically
limited to a single modality. Computational approaches allow integration of diverse single …