Accelerated epigenetic aging in brain is associated with pre-mortem HIV-associated neurocognitive disorders

AJ Levine, A Quach, DJ Moore, CL Achim… - Journal of …, 2016 - Springer
HIV infection leads to age-related conditions in relatively young persons. HIV-associated
neurocognitive disorders (HAND) are considered among the most prevalent of these …

Reductions in gray matter linked to epigenetic HIV-associated accelerated aging

BJ Lew, MD Schantell, J O'Neill, B Morsey… - Cerebral …, 2021 - academic.oup.com
A growing literature suggests a relationship between HIV-infection and a molecular profile of
age acceleration. However, despite the widely known high prevalence of HIV-related brain …

HIV-1 infection accelerates age according to the epigenetic clock

S Horvath, AJ Levine - The Journal of infectious diseases, 2015 - academic.oup.com
Background. Infection with human immunodeficiency virus type 1 (HIV) is associated with
clinical symptoms of accelerated aging, as evidenced by the increased incidence and …

Older individuals with HIV infection have greater memory deficits than younger individuals

IL Tan, BR Smith, E Hammond… - Journal of …, 2013 - Springer
The prevalence of HIV-associated neurocognitive disorder (HAND) remains persistently
high in the era of combination antiretroviral therapy. We aimed to characterize the pattern of …

[HTML][HTML] The effects of anti-retroviral therapy on epigenetic age acceleration observed in HIV-1-infected adults

ME Sehl, TM Rickabaugh, R Shih… - Pathogens and …, 2020 - ncbi.nlm.nih.gov
Background: HIV-1 infection is associated with acceleration of age-related methylation
patterns in peripheral blood and brain of infected individuals although the relative …

HIV, pathology and epigenetic age acceleration in different human tissues

S Horvath, DTS Lin, MS Kobor, JA Zoller, JW Said… - GeroScience, 2022 - Springer
Epigenetic clocks based on patterns of DNA methylation have great importance in
understanding aging and disease; however, there are basic questions to be resolved in their …

[HTML][HTML] Accelerated aging with HIV occurs at the time of initial HIV infection

EC Breen, ME Sehl, R Shih, P Langfelder, R Wang… - IScience, 2022 - cell.com
Living with HIV infection is associated with early onset of aging-related chronic conditions,
sometimes described as accelerated aging. Epigenetic DNA methylation patterns can …

Pathogenesis of age-related HIV neurodegeneration

M Mackiewicz, C Overk, CL Achim, E Masliah - Journal of neurovirology, 2019 - Springer
People over the age of 50 are the fastest growing segment of the HIV-infected population in
the USA. Although antiretroviral therapy has remarkable success controlling the systemic …

Epigenetic aging biomarkers associated with cognitive impairment in older African American adults with human immunodeficiency virus (HIV)

S Shiau, SM Arpadi, Y Shen, A Cantos… - Clinical Infectious …, 2021 - academic.oup.com
Background Accelerated epigenetic aging using DNA methylation (DNAm)-based
biomarkers has been reported in people with human immunodeficiency virus (HIV, PWH) …

Effect of ageing on neurocognitive function by stage of HIV infection: evidence from the Multicenter AIDS Cohort Study

K Goodkin, EN Miller, C Cox, S Reynolds, JT Becker… - The lancet HIV, 2017 - thelancet.com
Background The demographics of the HIV epidemic in the USA have shifted towards older
age. We aimed to establish the relationship between the processes of ageing and HIV …