Influenza infections are responsible for significant morbidity and mortality each year, with the
highest infection rates found in the elderly population. The main strategy to reduce the …

Influenza is an important contributor to morbidity and mortality worldwide. Accumulation of
genetic mutations termed antigenic drift, allows influenza viruses to inflict yearly epidemics …

Highlights•Aging is associated with a decline in immune function termed 'immune
senescence'.•Effective influenza vaccines need to be developed for better protection the …

The most profound consequences of immune senescence with respect to public health are
the increased susceptibility to influenza and loss of efficacy of the current split-virus …

Aging is associated with a decline in immune function (immunosenescence) that leads to
progressive deterioration in both innate and adaptive immune functions. These changes …

Immunosenescence is defined as the progressive deterioration of the immune system with
aging. Immunosenescence stifles the generation of protective B and T cell-mediated …

One of the most profound public health consequences of immune senescence is reflected in
an increased susceptibility to influenza and other acute respiratory illnesses, as well as a …

A number of protective immune functions decline with age along with physiological and
anatomical changes, contributing to the increased susceptibility of older adults to infectious …

Age-related declines in immune response pose a challenge in combating diseases later in
life. Influenza (flu) infection remains a significant burden on older populations and often …

Despite widespread influenza vaccination programs, influenza remains a major cause of
morbidity and mortality in older adults. Age-related changes in multiple aspects of the …