Current understanding of the innate control of toll-like receptors in response to SARS-CoV-2 infection

HE Jung, HK Lee - Viruses, 2021 - mdpi.com
The global coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute
respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection, threatens the entire world. It …

Toll-like receptor signaling in severe acute respiratory syndrome coronavirus 2-induced innate immune responses and the potential application value of toll-like …

J Dai, Y Wang, H Wang, Z Gao, Y Wang… - Frontiers in …, 2022 - frontiersin.org
Toll-like receptors (TLRs) are key sensors that recognize the pathogen-associated
molecular patterns (PAMPs) of severe acute respiratory syndrome coronavirus 2 (SARS …

Toll-like receptors (TLRs) as therapeutic targets for treating SARS-CoV-2: An immunobiological perspective

R Patra, NC Das, S Mukherjee - … –Volume I: Basic Science and Therapy …, 2022 - Springer
Abstract Introduction: Coronavirus disease-19 (COVID-19) caused by SARS-CoV-2 is
presently the biggest threat to mankind throughout the globe. Increasing reports on deaths …

An overview of recent insights into the response of TLR to SARS-CoV-2 infection and the potential of TLR agonists as SARS-CoV-2 vaccine adjuvants

MEH Kayesh, M Kohara, K Tsukiyama-Kohara - Viruses, 2021 - mdpi.com
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led
to coronavirus disease (COVID-19), a global health pandemic causing millions of deaths …

Toll-like receptor mediation in SARS-CoV-2: a therapeutic approach

A Manan, RH Pirzada, M Haseeb, S Choi - International journal of …, 2022 - mdpi.com
The innate immune system facilitates defense mechanisms against pathogen invasion and
cell damage. Toll-like receptors (TLRs) assist in the activation of the innate immune system …

[HTML][HTML] Role of toll-like receptor 7/8 pathways in regulation of interferon response and inflammatory mediators during SARS-CoV2 infection and potential therapeutic …

SR Dyavar, R Singh, R Emani, GP Pawar… - Biomedicine & …, 2021 - Elsevier
Abstract Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV2) is the causative
agent of Corona Virus Disease 2019 (COVID-19). Lower production of type I and III …

Toll-like receptors and COVID-19: a two-faced story with an exciting ending

L Onofrio, M Caraglia, G Facchini, V Margherita… - Future science …, 2020 - Taylor & Francis
Coronavirus disease 19 (COVID-19) is caused by a novel single-stranded RNA beta-
coronavirus called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)[1] …

TLRs: innate immune sentries against SARS-CoV-2 infection

S Mantovani, B Oliviero, S Varchetta, A Renieri… - International Journal of …, 2023 - mdpi.com
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), has been responsible for a devastating pandemic since March …

Role of toll‐like receptors in modulation of cytokine storm signaling in SARS‐CoV‐2‐induced COVID‐19

M Manik, RK Singh - Journal of medical virology, 2022 - Wiley Online Library
Balanced immune regulation is crucial for recognizing an invading pathogen, its killing, and
elimination. Toll‐like receptors (TLRs) are the key regulators of the innate immune system. It …

Innate receptor activation patterns involving TLR and NLR synergisms in COVID-19, ALI/ARDS and sepsis cytokine storms: a review and model making novel …

R Root-Bernstein - International journal of molecular sciences, 2021 - mdpi.com
Severe COVID-19 is characterized by a “cytokine storm”, the mechanism of which is not yet
understood. I propose that cytokine storms result from synergistic interactions among Toll …