Understanding why we age and how that process can be delayed or reversed are topics that
have engaged both researchers and the general public [1]. From a scientific perspective …

The aging immune system demonstrates a reduced capacity to mount a robust immune
response (immunosenescence), thereby increasing the susceptibility to various infectious …

An age‐related decline in immune functions, referred to as immunosenescence, is partially
responsible for the increased prevalence and severity of infectious diseases, and the low …

The effects of aging on the immune system are widespread and extend from hematopoietic
stem cells and lymphoid progenitors in the bone marrow and thymus to mature lymphocytes …

In the older adult, the benefits of vaccination to prevent infectious disease are limited, mainly
because of the adaptive immune system's inability to generate protective immunity. The age …

Accumulating data are documenting an inverse relationship between immune status,
response to vaccination, health, and longevity, suggesting that the immune system becomes …

Aging is associated with declines in immune system function, or 'immunosenescence',
leading to progressive deterioration in both innate and adaptive immunity. These changes …

Human immunosenescence contributes to morbidity and mortality in later life. The age-
associated increasing incidence ofcancer and cardiovascular disease plateaus at around 80 …

The effects of aging on the immune system are manifest at multiple levels that include
reduced production of B and T cells in bone marrow and thymus and diminished function of …

Aging is one of the principal unsolved enigmas remaining in cellular and molecular biology.
This challenge, and the potential for discoveries that may delay the onset or lessen the …