SARS-CoV-2 infection and persistence throughout the human body and brain

D Chertow, S Stein, S Ramelli, A Grazioli, JY Chung… - 2021 - researchsquare.com
COVID-19 is known to cause multi-organ dysfunction1-3 in acute infection, with prolonged
symptoms experienced by some patients, termed Post-Acute Sequelae of SARS-CoV-2 …

[HTML][HTML] SARS-CoV-2 infection and persistence in the human body and brain at autopsy

SR Stein, SC Ramelli, A Grazioli, JY Chung, M Singh… - Nature, 2022 - nature.com
Abstract Coronavirus disease 2019 (COVID-19) is known to cause multi-organ dysfunction,–
during acute infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) …

What can we learn from brain autopsies in COVID-19?

SS Mukerji, IH Solomon - Neuroscience letters, 2021 - Elsevier
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of
coronavirus disease 2019 (COVID-19) for which there have been over 50 million confirmed …

Neuroinvasion of SARS-CoV-2 in human and mouse brain

E Song, C Zhang, B Israelow, A Lu-Culligan… - Journal of Experimental …, 2021 - rupress.org
Although COVID-19 is considered to be primarily a respiratory disease, SARS-CoV-2 affects
multiple organ systems including the central nervous system (CNS). Yet, there is no …

[HTML][HTML] A cohort autopsy study defines COVID-19 systemic pathogenesis

XH Yao, T Luo, Y Shi, ZC He, R Tang, PP Zhang, J Cai… - Cell research, 2021 - nature.com
Severe COVID-19 disease caused by SARS-CoV-2 is frequently accompanied by
dysfunction of the lungs and extrapulmonary organs. However, the organotropism of SARS …

[HTML][HTML] Mapping of SARS-CoV-2 brain invasion and histopathology in COVID-19 disease

GE Serrano, JE Walker, R Arce, MJ Glass, D Vargas… - MedRxiv, 2021 - ncbi.nlm.nih.gov
Abstract The coronavirus SARS-CoV-2 (SCV2) causes acute respiratory distress, termed
COVID-19 disease, with substantial morbidity and mortality. As SCV2 is related to previously …

[PDF][PDF] The brain, another potential target organ, needs early protection from SARS-CoV-2 neuroinvasion

Z Li, Y Huang, X Guo - Sci China Life Sci, 2020 - researchgate.net
With the outbreak of the novel coronavirus disease (COVID-19) in China and rapid spread in
other countries around the world, humans are engaged in a life-and-death battle with the …

[HTML][HTML] The origin and underlying driving forces of the SARS-CoV-2 outbreak

SM Chaw, JH Tai, SL Chen, CH Hsieh… - Journal of biomedical …, 2020 - Springer
Background SARS-CoV-2 began spreading in December 2019 and has since become a
pandemic that has impacted many aspects of human society. Several issues concerning the …

[HTML][HTML] Neuropathology and virus in brain of SARS-CoV-2 infected non-human primates

I Rutkai, MG Mayer, LM Hellmers, B Ning… - Nature …, 2022 - nature.com
Neurological manifestations are a significant complication of coronavirus disease (COVID-
19), but underlying mechanisms aren't well understood. The development of animal models …

[HTML][HTML] Detection of SARS-CoV-2 viral proteins and genomic sequences in human brainstem nuclei

A Emmi, S Rizzo, L Barzon, M Sandre… - npj Parkinson's …, 2023 - nature.com
Neurological manifestations are common in COVID-19, the disease caused by SARS-CoV-
2. Despite reports of SARS-CoV-2 detection in the brain and cerebrospinal fluid of COVID …