Aging is a complex process regulated by multiple cellular pathways, including the
proteostasis network. The proteostasis network consists of molecular chaperones, stress …

Ageing is a major risk factor for the development of many diseases, prominently including
neurodegenerative disorders such as Alzheimer disease and Parkinson disease. A hallmark …

All cells count on precise mechanisms that regulate protein homeostasis to maintain a stable
and functional proteome. Alterations in these fine-tuned mechanisms underlie the …

Protein misfolding and aggregation as a consequence of impaired protein homeostasis
(proteostasis) not only characterizes numerous age-related diseases but also the aging …

Accumulation of intracellular damage is an almost universal hallmark of aging. An improved
understanding of the systems that contribute to cellular protein quality control has shed light …

Aging results in a decline of cellular proteostasis capacity which culminates in the
accumulation of phototoxic material, causing the onset of age-related maladies and …

The functional health of the proteome is determined by properties of the proteostasis
network (PN) that regulates protein synthesis, folding, macromolecular assembly …

What molecular processes drive cell aging and death? Here, we model how proteostasis—
ie, the folding, chaperoning, and maintenance of protein function—collapses with age from …

Ensuring cellular protein homeostasis, or proteostasis, requires precise control of protein
synthesis, folding, conformational maintenance, and degradation. A complex and adaptive …

Aging is a major risk factor for cancer development. As dysfunction in protein homeostasis,
or proteostasis, is a universal hallmark of both the aging process and cancer, a …