Folate‐mediated one‐carbon metabolism (FOCM) comprises a network of interconnected
folate‐dependent metabolic pathways responsible for serine and glycine interconversion, de …

One-carbon (1C) metabolism, mediated by the folate cofactor, supports multiple
physiological processes. These include biosynthesis (purines and thymidine), amino acid …

Tetrahydrofolate (THF) polyglutamates are a family of cofactors that carry and chemically
activate one‐carbon units for biosynthesis. THF‐mediated one‐carbon metabolism is a …

Folate metabolism is crucial for many biochemical processes, including purine and
thymidine monophosphate (dTMP) biosynthesis, mitochondrial protein translation, and …

Highlights•Cellular metabolism is reprogrammed to support tumorigenesis.•Folate fulfill
many metabolic requirements of proliferating cells and relevant metabolic pathway affect …

Impairments in folate-mediated 1-carbon metabolism are associated with several common
diseases and developmental anomalies including intestinal cancers, vascular disease …

The role of metabolic compartmentation in spatially organizing metabolic enzymes into
pathways, regulating flux through metabolic pathways, and controlling the partitioning of …

Folic acid is an essential vitamin for a wide spectrum of biochemical reactions; however,
unlike bacteria and plants, mammals are devoid of folate biosynthesis and thus must obtain …

Impaired folate-mediated 1-carbon metabolism has been linked to multiple disease
outcomes. A better understanding of the nutritional and genetic influences on this complex …

Cellular folate deficiency impairs one-carbon metabolism, resulting in decreased fidelity of
DNA synthesis and inhibition of numerous S-adenosylmethionine-dependent methylation …