Currently up to one‐third of colorectal cancer patients present with locally advanced or
metastatic disease that precludes a surgical cure. Performance limitations and low uptake of …

Colorectal cancer (CRC) is the second leading cause of cancer death worldwide that is
attributed to gradual long‐term accumulation of both genetic and epigenetic changes. To …

Colorectal cancer (CRC) arises as a consequence of the accumulation of genetic and
epigenetic alterations in colonic epithelial cells during neoplastic transformation. Epigenetic …

Colorectal cancer (CRC) is a common malignancy. It arises from benign neoplasms and
evolves into adenocarcinomas through a stepwise histological progression sequence …

Colorectal cancer (CRC) is one of the deadliest malignancies worldwide, ranking third in
incidence and second in mortality. Remarkably, early stage localized CRC has a 5-year …

Aberrant DNA methylation is frequently detected in gastrointestinal tumors, and can
therefore potentially be used to screen, diagnose, prognosticate, and predict colorectal …

Despite the recent advances in the therapeutic modalities, colorectal cancer (CRC) remains
to be one of the most common causes of cancer-related death. CRC arises through …

DNA methylation, the modification of a cytosine nucleotide immediately preceding a guanine
base in a stretch of DNA, is rapidly gaining strength in the diagnostic field as a powerful tool …

Epigenetic changes, including DNA methylation, influence the structure of chromatin, gene
expression and genomic stability. It appears that the abnormal pattern of DNA methylation …

Statistics rate colorectal adenocarcinoma as the most common cause of cancer death on
exclusion of smoking‐related neoplasia. However, the reported accumulation of genetic …