We undertook a genome-wide association study (GWAS) of parental longevity in European
descent UK Biobank participants. For combined mothers' and fathers' attained age, 10 loci …

Clear evidence exists for heritability of human longevity, and much interest is focused on
identifying genes associated with longer lives. To identify such longevity alleles, we …

Variation in human lifespan is 20 to 30% heritable in twins but few genetic variants have
been identified. We undertook a Genome Wide Association Study (GWAS) using age at …

Aging populations face diminishing quality of life due to increased disease and morbidity.
These challenges call for longevity research to focus on understanding the pathways …

Research into the genetic component of human longevity can provide important insights in
mechanisms that may protect against age-related diseases and multi-morbidity. Thus far …

Understanding the genetic basis of human longevity remains a challenge but could lead to
life-extending interventions and better treatments for age-related diseases. Toward this end …

Human longevity is heritable, but genome-wide association (GWA) studies have had limited
success. Here, we perform two meta-analyses of GWA studies of a rigorous longevity …

There is an intense search for longevity genes in both animal models and humans. Human
family studies have indicated that a modest amount of the overall variation in adult lifespan …

Background Family studies and heritability estimates provide evidence for a genetic
contribution to variation in the human life span. Methods We conducted a genome wide …

Given the rising rate of survival into advanced old age in the United States, achieving
longevity and healthy aging is becoming increasingly important. Besides maintaining …