Impaired innate antiviral defenses in COVID-19: Causes, consequences and therapeutic opportunities

IE Galani, E Andreakos - Seminars in Immunology, 2021 - Elsevier
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a recently emerged
pathogen that has caused coronavirus disease 2019 (COVID-19), the worst pandemic of our …

Innate and adaptive immunity to SARS-CoV-2 and predisposing factors

J Shen, J Fan, Y Zhao, D Jiang, Z Niu, Z Zhang… - Frontiers in …, 2023 - frontiersin.org
The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory
syndrome coronavirus (SARS-CoV-2), has affected all countries worldwide. Although some …

Innate immunology in COVID-19—a living review. Part I: viral entry, sensing and evasion

C Coveney, M Tellier, F Lu… - Oxford Open …, 2020 - academic.oup.com
The coronavirus infectious disease 2019 (COVID-19) pandemic caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) remains a world health concern and can …

Innate immunity in protection and pathogenesis during coronavirus infections and COVID-19

RKS Malireddi, BR Sharma… - Annual Review of …, 2024 - annualreviews.org
The COVID-19 pandemic was caused by the recently emerged β-coronavirus SARS-CoV-2.
SARS-CoV-2 has had a catastrophic impact, resulting in nearly 7 million fatalities worldwide …

Covid-19: perspectives on innate immune evasion

N Taefehshokr, S Taefehshokr, N Hemmat… - Frontiers in …, 2020 - frontiersin.org
The ongoing outbreak of Coronavirus disease 2019 infection achieved pandemic status on
March 11, 2020. As of September 8, 2020 it has caused over 890,000 mortalities world-wide …

The battle between host and SARS-CoV-2: Innate immunity and viral evasion strategies

S Zhang, L Wang, G Cheng - Molecular therapy, 2022 - cell.com
The SARS-CoV-2 virus, the pathogen causing COVID-19, has caused more than 200 million
confirmed cases, resulting in more than 4.5 million deaths worldwide by the end of August …

Innate immune recognition against SARS-CoV-2

T Yamada, A Takaoka - Inflammation and Regeneration, 2023 - Springer
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is the causative virus of
pandemic acute respiratory disease called coronavirus disease 2019 (COVID-19). Most of …

The molecular mechanism of SARS-CoV-2 evading host antiviral innate immunity

W Gu, H Gan, Y Ma, L Xu, ZJ Cheng, B Li, X Zhang… - Virology journal, 2022 - Springer
Abstract The newly identified Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-
CoV-2) has resulted in a global health emergency (COVID-19) because of its rapid spread …

Hallmarks of Severe COVID-19 Pathogenesis: A Pas de Deux Between Viral and Host Factors

R Rovito, M Augello, A Ben-Haim, V Bono… - Frontiers in …, 2022 - frontiersin.org
Two years into Coronavirus Disease 2019 (COVID-19) pandemic, a comprehensive
characterization of the pathogenesis of severe and critical forms of COVID-19 is still missing …

SARS-CoV-2 and innate immunity: the good, the bad, and the “goldilocks”

BL Sievers, MTK Cheng, K Csiba, B Meng… - Cellular & Molecular …, 2024 - nature.com
An ancient conflict between hosts and pathogens has driven the innate and adaptive arms of
immunity. Knowledge about this interplay can not only help us identify biological …