Background Chronological age is a prominent risk factor for many types of cancers including
colorectal cancer (CRC). Yet, the risk of CRC varies substantially between individuals, even …

Background: Epigenetic clock, or DNA methylation age, has been shown to highly correlate
with chronologic age. Epigenetic age acceleration, the difference between DNA methylation …

Simple Summary Racial disparities exist within colorectal cancer (CRC) incidence and
mortality, with African Americans (AA) exhibiting a greater risk of developing and dying from …

The incidence of cancer, adjusted for secular trends, is directly related to age, and advanced
chronologic age is one of the most significant risk factors for cancer. Organismal aging is …

Cancer is largely an aging disease. Accelerated biological aging may be the strongest
predictor of cancer and other chronic disease risks. In the absence of reliable and …

Simple Summary The role of DNA methylation in the carcinogenesis of colorectal cancer
(CRC) diagnosed< 50 years of age (early-onset CRC or EOCRC) is currently unknown. In …

Background We previously investigated the association between 5 “first-generation”
measures of epigenetic aging and cancer risk in the Melbourne Collaborative Cohort Study …

Accumulation of somatic mutations and genomic instability are hallmarks of both aging and
cancer. Epigenetic alterations occur across cell types and tissues with advancing age. DNA …

Aim of the study A vast majority of human malignancies are associated with ageing, and age
is a strong predictor of cancer risk. Recently, DNA methylation-based marker of ageing …

Background Human aging is associated with profound changes in one of the major
epigenetic mechanisms, DNA methylation. Some of these changes occur in a clock-like …