The sirtuin proteins constitute class III histone deacetylases (HDACs). These evolutionarily
conserved NAD+-dependent enzymes form an important component in a variety of cellular …

Sirtuins, initially described as histone deacetylases and gene silencers in yeast, are now
known to have many more functions and to be much more abundant in living organisms. The …

Sirtuins are NAD-dependent deacetylases that are highly conserved from bacteria to human
and SIR2 was originally shown to extend lifespan in budding yeast (Imai et al., 2000; …

Sirtuins (SIRT) belonging to the NAD+ dependent histone deacetylase III class of enzymes
have emerged as master regulators of metabolism and longevity. However, their role in …

Ever since the discovery of sirtuins a decade ago, interest in this family of NAD-dependent
deacetylases has exploded, generating multiple lines of evidence implicating sirtuins as …

Since healthy aging remains one of the ideals of modern society, both, the
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Sirtuins have been the focus of intense scrutiny since the discovery of Sir2 as a yeast
longevity factor. Functioning as either deacetylases or ADP ribosylases, Sirtuins are …

Sirtuins are a family of NAD+‐dependent protein deacetylases that regulate cellular
functions through deacetylation of a wide range of protein targets. Overexpression of Sir2 …

Aging has been a subject of interest since primordial times. More recently, it became clear
that aging is the major known risk factor for several neurodegenerative disorders, such as …

Sirtuins or Sir2 family of proteins are a class of NAD+ dependent protein deacetylases which
are evolutionarily conserved from bacteria to humans. Some sirtuins also exhibit mono-ADP …