Migrasomes trigger innate immune activation and mediate transmission of senescence signals across human cells

X Liu, H Jiao, B Zhang, S Zhang, K Yan, J Qu… - Life …, 2023 - academic.oup.com
Aging is a complex and heterogeneous process, raising important questions about how
aging is differently impacted by underlying genetics and external factors. Recently …

Migrasomes: from biogenesis, release, uptake, rupture to homeostasis and diseases

Y Zhang, W Guo, M Bi, W Liu, L Zhou… - Oxidative Medicine …, 2022 - Wiley Online Library
Migrasomes are migration‐dependent membrane‐bound vesicular structures that contain
cellular contents and small vesicles. Migrasomes grow on the tips or intersections of the …

[HTML][HTML] Migrasomes, a new mode of intercellular communication

Y Jiang, X Liu, J Ye, Y Ma, J Mao, D Feng… - Cell Communication and …, 2023 - Springer
Migrasomes are newly discovered extracellular vesicles (EVs) that are formed in migrating
cells and mediate intercellular communication. However, their size, biological generation …

[HTML][HTML] Migrasomes from adipose derived stem cells enrich CXCL12 to recruit stem cells via CXCR4/RhoA for a positive feedback loop mediating soft tissue …

Y Chen, Y Li, B Li, D Hu, Z Dong, F Lu - Journal of Nanobiotechnology, 2024 - Springer
Background Adipose-derived stem cells (ASCs) represent the most advantageous choice for
soft tissue regeneration. Studies proved the recruitment of ASCs post tissue injury was …

[HTML][HTML] Research progress of migrasomes: from genesis to formation, physiology to pathology

H Tang, Z Huang, M Wang, X Luan, Z Deng… - Frontiers in Cell and …, 2024 - frontiersin.org
Migrasomes are recently identified organelles that form at the ends or forks of retraction
fibers (RFs) behind migrating cells and are expelled from the cell through cell migration …

[HTML][HTML] When aging gets on the way of disposal: Senescent cell suppression of efferocytosis

CV Rothlin, S Ghosh - The Journal of Cell Biology, 2023 - ncbi.nlm.nih.gov
Chronic senescence can trigger pathological inflammation. In this issue, Schloesser et
al.(2022. J. Cell Biol. https://doi. org/10.1083/jcb. 202207097) demonstrate that senescent …

Cellular senescence in age-related disorders

J Kaur, JN Farr - Translational Research, 2020 - Elsevier
Much of the population is now faced with an enormous burden of age-associated chronic
diseases. Recent discoveries in geroscience indicate that healthspan in model organisms …

[HTML][HTML] Rejuvenation of the aged brain immune cell landscape in mice through p16-positive senescent cell clearance

X Zhang, VM Pearsall, CM Carver, EJ Atkinson… - Nature …, 2022 - nature.com
Cellular senescence is a plausible mediator of inflammation-related tissue dysfunction. In
the aged brain, senescent cell identities and the mechanisms by which they exert adverse …

[HTML][HTML] Senescent cells as promising targets to tackle age-related diseases

E Prašnikar, J Borišek, A Perdih - Ageing Research Reviews, 2021 - Elsevier
As the world's population progressively ages, the burden on the socio-economic and health
systems is escalating, demanding sustainable and lasting solutions. Cellular senescence …

[HTML][HTML] Spreading Senescent Cells' Burden and Emerging Therapeutic Targets for Frailty

S Marcozzi, G Bigossi, ME Giuliani, G Lai, R Giacconi… - Cells, 2023 - mdpi.com
The spreading of senescent cells' burden holds profound implications for frailty, prompting
the exploration of novel therapeutic targets. In this perspective review, we delve into the …