Administration of metformin increases healthspan and lifespan in model systems, and
evidence from clinical trials and observational studies suggests that metformin delays a …

Metformin is the most widely prescribed oral hypoglycemic medication for type 2 diabetes
worldwide. Metformin also retards aging in model organisms and reduces the incidence of …

The numerous beneficial health outcomes associated with the use of metformin to treat
patients with type 2 diabetes (T2DM), together with data from pre-clinical studies in animals …

Metformin is a drug commonly prescribed to treat patients with type 2 diabetes. Here we
show that long-term treatment with metformin (0.1% w/w in diet) starting at middle age …

Chronic 1% metformin treatment is nephrotoxic in mice, but this dose may nonetheless
confer health benefits if given intermittently rather than continuously. Here, we examined the …

In a world where the population is ageing, there is growing interest and demand for research
evaluating strategies that address the ageing process. After 60 years of successful use of …

Metformin, an anti-diabetes drug, has been recently emerging as a potential “anti-aging”
intervention based on its reported beneficial actions against aging in preclinical studies …

Aging has been targeted by genetic and dietary manipulation and by drugs in order to
increase lifespan and health span in numerous models. Metformin, which has demonstrated …

Even though the inevitable process of aging by itself cannot be considered a disease, it is
directly linked to life span and is the driving force behind all age-related diseases. It is an …

Abstract Purpose of Review Metformin has multiple benefits for health beyond its anti-
hyperglycemic properties. The purpose of this manuscript is to review the mechanisms that …