Twin studies show that genetic differences account for about a quarter of the variance in
adult human lifespan. Common polymorphisms that have a modest effect on lifespan have …

Research into the genetic component of human longevity can provide important insights in
mechanisms that may protect against age-related diseases and multi-morbidity. Thus far …

The exceptional longevity of centenarians is due in part to inherited genetic factors, as
deduced from data that show that first degree relatives of centenarians live longer and have …

Clear evidence exists for heritability of human longevity, and much interest is focused on
identifying genes associated with longer lives. To identify such longevity alleles, we …

We present a massive investigation into the genetic basis of human lifespan. Beginning with
a genome-wide association (GWA) study using a de-identified snapshot of the unique …

The field of the “epidemiology of longevity” has been expanding rapidly in recent years.
Several long-term cohort studies have followed older adults long enough to identify the most …

Given the rising rate of survival into advanced old age in the United States, achieving
longevity and healthy aging is becoming increasingly important. Besides maintaining …

This paper reviews the recent literature on genes and longevity. The influence of genes on
human life span has been confirmed in studies of life span correlation between related …

Complex diseases are major contributors to human mortality in old age. Paradoxically, many
genetic variants that have been associated with increased risks of such diseases are found …

Longevity and healthy aging are among the most complex phenotypes studied to date. The
heritability of age at death in adulthood is approximately 25%. Studies of exceptionally long …