Systematic evaluation of DNA methylation age estimation with common preprocessing methods and the Infinium MethylationEPIC BeadChip array
Background The capacity of technologies measuring DNA methylation (DNAm) is rapidly
evolving, as are the options for applicable bioinformatics methods. The most commonly used …
evolving, as are the options for applicable bioinformatics methods. The most commonly used …
New targeted approaches for epigenetic age predictions
Background Age-associated DNA methylation changes provide a promising biomarker for
the aging process. While genome-wide DNA methylation profiles enable robust age …
the aging process. While genome-wide DNA methylation profiles enable robust age …
Epigenetic age acceleration predicts cancer, cardiovascular, and all-cause mortality in a German case cohort
L Perna, Y Zhang, U Mons, B Holleczek, KU Saum… - Clinical …, 2016 - Springer
Background Previous studies have developed models predicting methylation age from DNA
methylation in blood and other tissues (epigenetic clock) and suggested the difference …
methylation in blood and other tissues (epigenetic clock) and suggested the difference …
The frailty index outperforms DNA methylation age and its derivatives as an indicator of biological age
S Kim, L Myers, J Wyckoff, KE Cherry, SM Jazwinski - Geroscience, 2017 - Springer
The measurement of biological age as opposed to chronological age is important to allow
the study of factors that are responsible for the heterogeneity in the decline in health and …
the study of factors that are responsible for the heterogeneity in the decline in health and …
Genetic and environmental causes of variation in epigenetic aging across the lifespan
Background DNA methylation-based biological age (DNAm age) is an important biomarker
for adult health. Studies in specific age ranges have found widely varying results about its …
for adult health. Studies in specific age ranges have found widely varying results about its …
Methylation‐based estimated biological age and cardiovascular disease
L Lind, E Ingelsson, J Sundström… - European Journal of …, 2018 - Wiley Online Library
Background DNA methylation changes over life at specific sites in the genome, which can
be used to estimate “biological age.” The aim of this population‐based longitudinal cohort …
be used to estimate “biological age.” The aim of this population‐based longitudinal cohort …
Aging of blood can be tracked by DNA methylation changes at just three CpG sites
Background Human aging is associated with DNA methylation changes at specific sites in
the genome. These epigenetic modifications may be used to track donor age for forensic …
the genome. These epigenetic modifications may be used to track donor age for forensic …
Obesity accelerates epigenetic aging in middle-aged but not in elderly individuals
T Nevalainen, L Kananen, S Marttila, J Jylhävä… - Clinical …, 2017 - Springer
Background Human aging is associated with profound changes in one of the major
epigenetic mechanisms, DNA methylation. Some of these changes occur in a clock-like …
epigenetic mechanisms, DNA methylation. Some of these changes occur in a clock-like …
Assessment of epigenetic clocks as biomarkers of aging in basic and population research
ME Levine - The Journals of Gerontology: Series A, 2020 - academic.oup.com
The Geoscience paradigm suggests that targeting the aging process could delay or prevent
the risk of multiple major age-related diseases, such as cancer, cardiovascular disease …
the risk of multiple major age-related diseases, such as cancer, cardiovascular disease …
Methylation-based biological age and hypertension prevalence and incidence
Background: Hypertension is common in older individuals and is a major risk factor for
cardiovascular disease. Blood DNA methylation profiles have been used to derive metrics of …
cardiovascular disease. Blood DNA methylation profiles have been used to derive metrics of …