Age predictors based on DNA methylation levels at a small set of CpG sites, DNAm clocks,
have been developed for humans and extended to several other species. Three currently …

Rationale: Epigenetic aging is a novel measure of biological age, reflecting exposures and
disease risks independent of chronological age. It may serve as a useful biomarker of …

Recent research suggests that epigenetics, especially DNA methylation, plays a mechanistic
role in aging. Epigenetic clocks, which measure changes in a few hundred specific CpG …

Individuals of the same chronological age exhibit disparate rates of biological ageing.
Consequently, a number of methodologies have been proposed to determine biological age …

DNA methylation-based (DNAm) measures of biological aging associate with increased risk
of morbidity and mortality, but their links with cognitive decline are less established. This …

Recent research efforts provided compelling evidence of genome-wide DNA methylation
alterations in aging and age-related disease. It is currently well established that DNA …

Markers of biological aging have potential utility in primary care and public health. We
developed a model of age based on untargeted metabolic profiling across multiple …

The association between aging and cancer is complex. Recent studies have developed
measures of biological aging based on DNA methylation and called them “age …

Background Epigenetic clocks based on DNA methylation yield high correlations with
chronological age in cross-sectional data. Due to a paucity of longitudinal data, it is not …

DNA methylation has been identified as the most promising molecular biomarker for the
prediction of age. Several DNA methylation-based models have been proposed for age …