Ageing of the global population has become a public health concern with an important socio-
economic dimension. Ageing is characterized by an increase in the concentration of …

Ageing is characterized by a low-grade chronic inflammation marked by elevated circulating
levels of inflammatory mediators. This chronic inflammation occurring in the absence of …

A typical feature of ageing is a chronic, low-grade inflammation characterized by a general
increase in the production of proinflammatory cytokines and inflammatory markers (“inflamm …

Background Old age is characterized by a peculiar low-grade, chronic, and “sterile”
inflammatory state, which has been termed “inflammaging.” This is believed to substantially …

Ageing and age-related diseases share some basic mechanistic pillars that largely
converge on inflammation. During ageing, chronic, sterile, low-grade inflammation—called …

Cytokine dysregulation is believed to play a key role in the remodeling of the immune
system at older age, with evidence pointing to an inability to fine-control systemic …

Extrinsic factors, such as lifestyle and diet, are shown to be essential in the control of human
healthy aging, and thus, longevity. They do so by targeting at least in part the gut …

The aging process is driven by multiple mechanisms that lead to changes in energy
production, oxidative stress, homeostatic dysregulation and eventually to loss of functionality …

Both the innate and adaptive immune systems decline with age, causing greater
susceptibility to infectious diseases and reduced responses to vaccination. Diseases are …

Highlights•Elderly people commonly show signs of low level systemic inflammation.•Causes
include presence of senescent cells, chronic infections and obesity.•Systemic inflammation …