Age is the strongest risk factor for many diseases including neurodegenerative disorders,
coronary heart disease, type 2 diabetes and cancer. Due to increasing life expectancy and …

Human aging and longevity are complex and multi-factorial traits that result from a
combination of environmental, genetic, epigenetic and stochastic factors, each contributing …

Aging results in various deleterious changes in the human body that may lead to loss of
function and the manifestation of chronic diseases. While diseases can generally be reliably …

Age is the single greatest risk factor for a wide range of diseases, and as the mean age of
human populations grows steadily older, the impact of this risk factor grows as well …

Significance: Aging is a complex trait that is influenced by a combination of genetic and
environmental factors. Although many cellular and physiological changes have been …

Age is the key risk factor for diseases and disabilities of the elderly. Efforts to tackle age-
related diseases and increase healthspan have suggested targeting the ageing process …

The aging process has been linked to the occurrence of chronic diseases and functional
impairments, including cancer, sarcopenia, frailty, metabolic, cardiovascular, and …

Normal ageing is associated with diverse physiological changes in all organ systems but the
rate and extent of these changes vary markedly among individuals. One aspect of ageing …

Organismal aging is driven by interconnected molecular changes encompassing internal
and extracellular factors. Combinational analysis of high-throughput 'multi-omics' datasets …

Human lifespan variation is mainly determined by environmental factors, whereas the
genetic contribution is 25–30% and expected to be polygenic. Two complementary fields go …