Biomarkers for aging identified in cross-sectional studies tend to be non-causative
PG Nelson, DEL Promislow… - The Journals of …, 2020 - academic.oup.com
Biomarkers are important tools for diagnosis, prognosis, and identification of the causal
factors of physiological conditions. Biomarkers are typically identified by correlating …
factors of physiological conditions. Biomarkers are typically identified by correlating …
The INSPIRE bio-resource research platform for healthy aging and geroscience: focus on the human translational research cohort (The INSPIRE-T Cohort)
S Guyonnet, Y Rolland, C Takeda, PJ Ousset… - The Journal of frailty & …, 2021 - Springer
Abstract Background The Geroscience field focuses on the core biological mechanisms of
aging, which are involved in the onset of age-related diseases, as well as declines in …
aging, which are involved in the onset of age-related diseases, as well as declines in …
A robust machine learning framework to identify signatures for frailty: a nested case-control study in four aging European cohorts
Phenotype-specific omic expression patterns in people with frailty could provide invaluable
insight into the underlying multi-systemic pathological processes and targets for intervention …
insight into the underlying multi-systemic pathological processes and targets for intervention …
Research priorities for measuring biologic age: summary and future directions from the Research Centers Collaborative Network Workshop
Biologic aging reflects the genetic, molecular, and cellular changes underlying the
development of morbidity and mortality with advancing chronological age. As several …
development of morbidity and mortality with advancing chronological age. As several …
The developmental aging and origins of health and disease hypotheses explained by different protein networks
One theory that attempts to explain how and why an organism ages is the developmental
hypothesis of aging (DevAge), which describes how developmental programming leads to …
hypothesis of aging (DevAge), which describes how developmental programming leads to …
Aging biomarkers and the brain
Quantifying biological aging is critical for understanding why aging is the primary driver of
morbidity and mortality and for assessing novel therapies to counter pathological aging. In …
morbidity and mortality and for assessing novel therapies to counter pathological aging. In …
Towards a gene expression biomarker set for human biological age
We have previously described a statistical model capable of distinguishing young (age< 65
years) from old (age≥ 75 years) individuals. Here we studied the performance of a modified …
years) from old (age≥ 75 years) individuals. Here we studied the performance of a modified …
Oxidative stress in aging: advances in proteomic approaches
D Ortuño-Sahagún, M Pallàs… - … Medicine and Cellular …, 2014 - Wiley Online Library
Aging is a gradual, complex process in which cells, tissues, organs, and the whole organism
itself deteriorate in a progressive and irreversible manner that, in the majority of cases …
itself deteriorate in a progressive and irreversible manner that, in the majority of cases …
Ranking biomarkers of aging by citation profiling and effort scoring
A Hartmann, C Hartmann, R Secci, A Hermann… - Frontiers in …, 2021 - frontiersin.org
Aging affects most living organisms and includes the processes that reduce health and
survival. The chronological and the biological age of individuals can differ remarkably, and …
survival. The chronological and the biological age of individuals can differ remarkably, and …