Background Mammalian species exhibit a wide range of lifespans. To date, a robust and
dynamic molecular readout of these lifespan differences has not yet been identified. Recent …

DNA methylation‐based biomarkers of ageing (epigenetic clocks) promise to lead to new
insights into evolutionary biology of ageing. Relatively little is known about how the natural …

DNA methylation (DNAm) is a key mechanism for regulating gene expression in animals
and levels are known to change with age. Recent studies have used DNAm changes as a …

Biological ageing and its mechanistic underpinnings are of immense biomedical and
ecological significance. Ageing involves the decline of diverse biological functions and …

Epigenetic approaches for estimating the age of living organisms are revolutionizing studies
of long‐lived species. Molecular biomarkers that allow age estimates from small tissue …

Cytosine methylation patterns have not yet been thoroughly studied in horses. Here, we
profile n= 333 samples from 42 horse tissue types at loci that are highly conserved between …

Several articles describe highly accurate age estimation methods based on human DNA-
methylation data. It is not yet known whether similar epigenetic aging clocks can be …

The degree to which species can rapidly adapt is key to survival in the face of climatic and
other anthropogenic changes. For little brown bats (Myotis lucifugus), whose populations …

Human DNA methylation profiles have been used successfully to develop highly accurate
biomarkers of aging (“epigenetic clocks”). Although these human epigenetic clocks are not …

Bats are unique among mammals, possessing some of the rarest mammalian adaptations,
including true self-powered flight, laryngeal echolocation, exceptional longevity, unique …