[HTML][HTML] Epigenetic-aging-signature to determine age in different tissues

CM Koch, W Wagner - Aging (Albany NY), 2011 - ncbi.nlm.nih.gov
All tissues of the organism are affected by aging. This process is associated with epigenetic
modifications such as methylation changes at specific cytosine residues in the DNA (CpG …

Dynamics of DNA methylation in recent human and great ape evolution

I Hernando-Herraez, J Prado-Martinez, P Garg… - PLoS …, 2013 - journals.plos.org
DNA methylation is an epigenetic modification involved in regulatory processes such as cell
differentiation during development, X-chromosome inactivation, genomic imprinting and …

DNA methylation and healthy human aging

MJ Jones, SJ Goodman, MS Kobor - Aging cell, 2015 - Wiley Online Library
The process of aging results in a host of changes at the cellular and molecular levels, which
include senescence, telomere shortening, and changes in gene expression. Epigenetic …

Seasonal variation in genome-wide DNA methylation patterns and the onset of seasonal timing of reproduction in great tits

HM Viitaniemi, I Verhagen, ME Visser… - Genome Biology and …, 2019 - academic.oup.com
In seasonal environments, timing of reproduction is a trait with important fitness
consequences, but we know little about the molecular mechanisms that underlie the …

Epigenetic aging signatures in mice livers are slowed by dwarfism, calorie restriction and rapamycin treatment

T Wang, B Tsui, JF Kreisberg, NA Robertson, AM Gross… - Genome biology, 2017 - Springer
Background Global but predictable changes impact the DNA methylome as we age, acting
as a type of molecular clock. This clock can be hastened by conditions that decrease …

Speciation dynamics during the global radiation of extant bats

JJ Shi, DL Rabosky - Evolution, 2015 - academic.oup.com
Species richness varies widely across extant clades, but the causes of this variation remain
poorly understood. We investigate the role of diversification rate heterogeneity in shaping …

Trends in DNA methylation with age replicate across diverse human populations

S Gopalan, O Carja, M Fagny, E Patin, JW Myrick… - Genetics, 2017 - academic.oup.com
Aging is associated with widespread changes in genome-wide patterns of DNA methylation.
Thousands of CpG sites whose tissue-specific methylation levels are strongly correlated with …

Comparative analysis of bat genomes provides insight into the evolution of flight and immunity

G Zhang, C Cowled, Z Shi, Z Huang, KA Bishop-Lilly… - Science, 2013 - science.org
Bats are the only mammals capable of sustained flight and are notorious reservoir hosts for
some of the world's most highly pathogenic viruses, including Nipah, Hendra, Ebola, and …

Global remodeling of the mouse DNA methylome during aging and in response to calorie restriction

A Sziráki, A Tyshkovskiy, VN Gladyshev - Aging cell, 2018 - Wiley Online Library
Aging is characterized by numerous molecular changes, such as accumulation of molecular
damage and altered gene expression, many of which are linked to DNA methylation. Here …

[PDF][PDF] The world goes bats: living longer and tolerating viruses

V Gorbunova, A Seluanov, BK Kennedy - Cell Metabolism, 2020 - cell.com
For centuries, people believed that bats possessed sinister powers. Bats are thought to be
ancestral hosts to many deadly viruses affecting humans including Ebola, rabies, and most …