[PDF][PDF] DNA methylation clocks in aging: categories, causes, and consequences
Age-associated changes to the mammalian DNA methylome are well documented and
thought to promote diseases of aging, such as cancer. Recent studies have identified …
thought to promote diseases of aging, such as cancer. Recent studies have identified …
A pan-tissue DNA-methylation epigenetic clock based on deep learning
Several age predictors based on DNA methylation, dubbed epigenetic clocks, have been
created in recent years, with the vast majority based on regularized linear regression. This …
created in recent years, with the vast majority based on regularized linear regression. This …
Epigenetic clock: DNA methylation in aging
S Jiang, Y Guo - Stem cells international, 2020 - Wiley Online Library
Aging, which is accompanied by decreased organ function and increased disease
incidence, limits human lifespan and has attracted investigators for thousands of years. In …
incidence, limits human lifespan and has attracted investigators for thousands of years. In …
Genome-wide association between DNA methylation and alternative splicing in an invertebrate
K Flores, F Wolschin, JJ Corneveaux, AN Allen… - BMC genomics, 2012 - Springer
Background Gene bodies are the most evolutionarily conserved targets of DNA methylation
in eukaryotes. However, the regulatory functions of gene body DNA methylation remain …
in eukaryotes. However, the regulatory functions of gene body DNA methylation remain …
[PDF][PDF] Using DNA methylation profiling to evaluate biological age and longevity interventions
The DNA methylation levels of certain CpG sites are thought to reflect the pace of human
aging. Here, we developed a robust predictor of mouse biological age based on 90 CpG …
aging. Here, we developed a robust predictor of mouse biological age based on 90 CpG …