Hallmarks of Severe COVID-19 Pathogenesis: A Pas de Deux Between Viral and Host Factors

R Rovito, M Augello, A Ben-Haim, V Bono… - Frontiers in …, 2022 - frontiersin.org
Two years into Coronavirus Disease 2019 (COVID-19) pandemic, a comprehensive
characterization of the pathogenesis of severe and critical forms of COVID-19 is still missing …

Mechanistic insights into the immune pathophysiology of COVID-19; an in-depth review

A Shafqat, S Shafqat, SA Salameh, J Kashir… - Frontiers in …, 2022 - frontiersin.org
Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), which causes
coronavirus-19 (COVID-19), has caused significant morbidity and mortality globally. In …

[HTML][HTML] Immunology of COVID-19: current state of the science

N Vabret, GJ Britton, C Gruber, S Hegde, J Kim… - Immunity, 2020 - cell.com
The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) has affected millions of people worldwide, igniting …

Pathogenesis guided therapeutic management of COVID-19: an immunological perspective

A Kumar, P Prasoon, PS Sekhawat… - International Reviews …, 2021 - Taylor & Francis
Lack of standardized therapeutic approaches is arguably the significant contributor to the
high burden of mortality observed in the ongoing pandemic of the Coronavirus disease …

Pathophysiology and clinical management of coronavirus disease (COVID-19): a mini-review

Y Zhu, L Sharma, D Chang - Frontiers in Immunology, 2023 - frontiersin.org
An unprecedented global pandemic caused by a novel coronavirus named SARS-CoV-2
has created a severe healthcare threat and become one of the biggest challenges to human …

Unraveling the mystery surrounding post-acute sequelae of COVID-19

RK Ramakrishnan, T Kashour, Q Hamid… - Frontiers in …, 2021 - frontiersin.org
More than one year since its emergence, corona virus disease 2019 (COVID-19) is still
looming large with a paucity of treatment options. To add to this burden, a sizeable subset of …

Impaired innate antiviral defenses in COVID-19: Causes, consequences and therapeutic opportunities

IE Galani, E Andreakos - Seminars in Immunology, 2021 - Elsevier
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a recently emerged
pathogen that has caused coronavirus disease 2019 (COVID-19), the worst pandemic of our …

Innate immunological pathways in COVID-19 pathogenesis

SR Paludan, TH Mogensen - Science immunology, 2022 - science.org
Coronavirus disease 2019 (COVID-19) is a disease characterized by a profound
dysregulation of the innate immune system. This knowledge has emerged from the large …

Immune response, inflammation, and the clinical spectrum of COVID-19

LF García - Frontiers in immunology, 2020 - frontiersin.org
The current COVID-19 pandemic began in December 2019 in Wuhan (China) and rapidly
extended to become a global sanitary and economic emergency. Its etiological agent is the …

Immune response in COVID-19: addressing a pharmacological challenge by targeting pathways triggered by SARS-CoV-2

M Catanzaro, F Fagiani, M Racchi, E Corsini… - Signal transduction and …, 2020 - nature.com
To date, no vaccines or effective drugs have been approved to prevent or treat COVID-19
and the current standard care relies on supportive treatments. Therefore, based on the fast …