Abstract Each year, almost 4.1 million people are diagnosed with gastrointestinal (GI)
cancers. Due to late detection of this disease, the mortality is high, causing approximately 3 …

Altered epigenetic regulation is central to many human diseases, including cancer. Over the
past two decade, major advances have been made in our understanding of the role of …

Colorectal cancer (CRC) is the second leading cause of cancer death worldwide that is
attributed to gradual long‐term accumulation of both genetic and epigenetic changes. To …

DNA methylation, the modification of a cytosine nucleotide immediately preceding a guanine
base in a stretch of DNA, is rapidly gaining strength in the diagnostic field as a powerful tool …

Aberrant DNA methylation is frequently detected in gastrointestinal tumors, and can
therefore potentially be used to screen, diagnose, prognosticate, and predict colorectal …

DNA methylation is an epigenetic mechanism regulating gene expression. Changes in DNA
methylation were suggested to be useful biomarkers for diagnosis, and for the determination …

Colorectal cancer (CRC) is one of the most prevalent malignancies in the world. CRC-
associated morbidity and mortality is continuously increasing, in part due to a lack of early …

Colorectal cancer (CRC) is one of the most common cancer worldwide and results from the
accumulation of mutations and epimutations in colonic mucosa cells ultimately leading to …

Since genetic and epigenetic alterations influence the development of colorectal cancer
(CRC), huge potential lies in the use of DNA methylation as biomarkers to improve the …

Despite the recent advances in the therapeutic modalities, colorectal cancer (CRC) remains
to be one of the most common causes of cancer-related death. CRC arises through …