Cancer chemotherapy has three main applications. It is curative for a small number of
malignancies including childhood leukemia, Hodgkin's and non-Hodgkin's lymphoma, and …

Background. Randomized clinical trials have shown the efficacy of adjuvant chemotherapy
in treating node-positive operable breast cancer in women aged≤ 69 years, but the benefit …

Despite increasing evidence of benefit from adjuvant chemotherapy, older women with
breast cancer are commonly given less aggressive treatment than younger patients …

BACKGROUND Older women with breast carcinoma are less likely than younger women to
receive adjuvant chemotherapy. The authors hypothesized that after controlling for …

Background Senescent cells, which express p16 INK4a, accumulate with aging and
contribute to age-related pathology. To understand whether cytotoxic agents promote …

Learning Objectives After completing this course, the reader will be able to: Describe several
methods for assessing a patient's comorbidity and functional status prior to adjuvant …

PURPOSE This study determines the survival benefit and cost-effectiveness of adjuvant
chemotherapy in elderly women with breast cancer. In addition, the analysis measures the …

Over 30 million cancer survivors exist worldwide. Survivors have an earlier onset and higher
incidence of chronic comorbidities, including endocrinopathies, cardiac dysfunction …

Background Few data are available on compliance and safety of adjuvant chemotherapy
when indicated in elderly breast cancer patients; CMF (cyclophosphamide, methotrexate …

PURPOSE: To consider the question of when to prescribe adjuvant treatment for elderly
breast cancer patients, particularly when comorbidities are present. Knowledge of the …