Highlights•Cellular senescence is a key cellular stress response pathway.•Senescent cells
produce various bioactive factors referred to collectively as the SASP.•The cGAS-STING …

Chromosomal instability (CIN) drives cancer cell evolution, metastasis and therapy
resistance, and is associated with poor prognosis. CIN leads to micronuclei that release …

Senescent cells alter their microenvironment by secreting a growing collection of factors, a
phenomenon termed the senescence-associated secretory phenotype (SASP). Cellular …

Chromosomal instability is a hallmark of cancer that results from ongoing errors in
chromosome segregation during mitosis. Although chromosomal instability is a major driver …

Cellular senescence is a stress-responsive cell-cycle arrest program that terminates the
further expansion of (pre-) malignant cells,. Key signalling components of the senescence …

The generation of DNA lesions and the resulting activation of DNA damage response (DDR)
pathways are both affected by the chromatin status at the site of damaged DNA. In turn, DDR …

Cellular senescence is a stable cell growth arrest. Senescent cells are metabolically active,
as exemplified by the secretion of inflammatory cytokines, chemokines, and growth factors …

During aging, the mechanisms that normally maintain health and stress resistance strikingly
decline, resulting in decrepitude, frailty, and ultimately death. Exactly when and how this …

The perpetuation of inflammation is an important pathophysiological contributor to the global
medical burden. Chronic inflammation is promoted by non-programmed cell death,; …

Age is a major risk factor for cancer. Alterations in DNA methylation, histone modifications,
chromatin structure, and epigenetic regulatory mechanisms are prominent hallmarks of both …