Normal cells can respond to expression of activated oncogenes by initiating cellular
senescence, a permanent state of proliferative arrest. But whether this process reflects a …

Increased apoptosis is known to contribute to age-related pathologies in post-mitotic tissues
such as brain 1. Although it has been postulated 2, 3, 4 experimental evidence for a decline …

The senescence of mammalian cells is characterized by a proliferative arrest in response to
stress and the expression of an inflammatory phenotype. Here we show that histone H2A. J …

Cellular senescence, which is characterized by an irreversible cell-cycle arrest
accompanied by a distinctive secretory phenotype, can be induced through various …

Abstract Cyclic GMP-AMP (cGAMP) synthase (cGAS) detects infections or tissue damage by
binding to microbial or self DNA in the cytoplasm. Upon binding DNA, cGAS produces …

Post-translational modifications of histone proteins and exchanges of histone variants of
chromatin are central to the regulation of nearly all DNA-templated biological processes …

Defective DNA damage response (DDR) signaling is a common mechanism that initiates
and maintains the cellular senescence phenotype. Dysfunctional telomeres activate DDR …

INTRODUCTION Complex multicellular organisms are subject to a myriad of cellular
stresses, which can be managed through cell-intrinsic adaptation and repair mechanisms …

Genomic instability is an important driver of ageing. The accumulation of DNA damage is
believed to contribute to ageing by inducing cell death, senescence and tissue dysfunction …

The DNA damage response is essential to safeguard genome integrity. Although the
contribution of chromatin in DNA repair has been investigated,, the contribution of …