Organismal ageing is associated with many physiological changes, including differences in
the immune system of most animals. These differences are often considered to be a key …

Successful vaccination of the elderly against important infectious pathogens that cause high
morbidity and mortality represents a growing public health priority. Building on the theme of …

A wide range of studies have demonstrated that human immunity can vary significantly
across demographics. In particular ageassociated declines of the immune system in older …

Highlights•Aging is associated with a decline in immune function termed 'immune
senescence'.•Effective influenza vaccines need to be developed for better protection the …

An age-related decline in immune responses in the elderly results in greater susceptibility to
infection and reduced responses to vaccination. This decline in immune function affects both …

A number of protective immune functions decline with age along with physiological and
anatomical changes, contributing to the increased susceptibility of older adults to infectious …

Aging is associated with declines in immune system function, or 'immunosenescence',
leading to progressive deterioration in both innate and adaptive immunity. These changes …

The age-related dysregulation and decline of the immune system—collectively termed
“immunosenescence”—has been generally associated with an increased susceptibility to …

The immune system of the elderly is particularly susceptible to infectious diseases and
displays reduced response to vaccination. The current vaccines, designed for young and …

Older adults are more susceptible to viral and bacterial infection, and experience higher
incidence and severity of infectious diseases. Although vaccination is the most logical …