The increased susceptibility of the elderly to infection presents a major challenge to public
health services. An aging immune system is well documented as the cause of increased …

Influenza is an important contributor to morbidity and mortality worldwide. Accumulation of
genetic mutations termed antigenic drift, allows influenza viruses to inflict yearly epidemics …

Aging is associated with a decline in immune function (immunosenescence) that leads to
progressive deterioration in both innate and adaptive immune functions. These changes …

In recent years, the elderly has become a rapidly growing proportion of the world's
population as life expectancy is extending. Immunosenescence and inflammaging …

One of the most appreciated consequences of immunosenescence is an impaired response
to vaccines with advanced age. While most studies report impaired antibody responses in …

The aging process in humans is associated with a decrease in immune function
(immunosenescence) and an increase in comorbid disorders. When combined with …

Background Aging is characterized by a progressive decline in the capacity of the immune
system to fight influenza virus infection and to respond to vaccination. Among the several …

The most profound consequences of immune senescence with respect to human health are
the increased susceptibility to infectious diseases and decreased vaccine efficacy. Changes …

The progressive increase of the aged population worldwide mandates new strategies to
ensure sustained health and well-being with age. The development of better and/or new …

One of the most profound public health consequences of immune senescence is reflected in
an increased susceptibility to influenza and other acute respiratory illnesses, as well as a …