A mutation in the LMNA gene is responsible for the most dramatic form of premature aging,
Hutchinson–Gilford progeria syndrome (HGPS). Several recent studies have suggested that …

Hutchinson–Gilford progeria syndrome (HGPS) is a rare genetic disorder phenotypically
characterized by many features of premature aging. Most cases of HGPS are due to a …

The relationship between progerias—diseases that resemble premature aging—and the
normal aging process has been a source of debate in the aging research community. A …

Products of the LMNA gene, primarily lamin A and C, are key components of the nuclear
lamina, a proteinaceous meshwork that underlies the inner nuclear membrane and is …

Cellular senescence is a hallmark of normal aging and aging-related syndromes, including
the premature aging disorder Hutchinson-Gilford Progeria Syndrome (HGPS), a rare genetic …

Abstract The transgenic Lmna G609G progeric mouse represents an outstanding animal
model for studying the human Hutchinson-Gilford Progeria Syndrome (HGPS) caused by a …

The Hutchinson–Gilford progeria syndrome (HGPS) is a premature aging disease caused by
mutations of the LMNA gene leading to increased production of a partially processed form of …

Hutchinson-Gilford progeria syndrome (HGPS), a devastating premature aging disease, is
caused by a point mutation in the lamin A gene (LMNA). This mutation constitutively …

Hutchinson-Gilford Progeria Syndrome (HGPS) is a rare premature aging disorder caused
by mutations in the gene LMNA, which encodes the nuclear matrix protein lamin A. Previous …

Most cases of the segmental progeroid syndrome, Hutchinson–Gilford progeria syndrome
(HGPS), are caused by a de novo dominant mutation within a single codon of the LMNA …