We and others have previously demonstrated that retinal cells can be derived from human
embryonic stem cells (hESCs) and induced pluripotent stem cells under defined culture …

The mature, functional, and healthy eye is generated by the coordinated regulatory
interaction of numerous and diverse developing tissues. The neural retina of the eye must …

The development of single-cell RNA sequencing (scRNA-seq) has allowed high-resolution
analysis of cell-type diversity and transcriptional networks controlling cell-fate specification …

The scarcity of embryonic/foetal material as a resource for direct study means that there is
still limited understanding of human retina development. Here, we present an integrated …

Purpose: Retinal organoids generated from human pluripotent stem cells exhibit
considerable variability during differentiation. Our goals are to assess developmental …

The Rx and pax6 homeobox genes are among the earliest genes expressed in the eye
primordia and play crucial roles in the specification of ocular fate. These genes exhibit …

Eye development has been a paradigm for the study of organogenesis, from the
demonstration of lens induction through epithelial tissue morphogenesis, to neuronal …

Embryonic stem cells have the potential to give rise to all cell lineages when introduced into
the early embryo. They also give rise to a limited number of different cell types in vitro in …

Purpose Retinal organoids (ROs) derived from human pluripotent stem cells largely
recapitulate key features of in vivo retinal development, thus permitting the study of …

Organ formation is a multi-scale event that involves changes at the intracellular, cellular and
tissue level. Organogenesis often starts with the formation of characteristically shaped organ …