The coordination of proliferation and cell fate specification is of particular importance in the
developing central nervous system, because different classes of neurons are generated at …

Vertebrate retinal pigment epithelium (RPE) cells are derived from the multipotent optic
neuroepithelium, develop in close proximity to the retina, and are indispensible for eye …

Recent studies demonstrated a number of links between chromatin structure, gene
expression, extracellular signaling and cellular differentiation during lens development …

Human pluripotent stem cells have the potential to provide comprehensive model systems
for the earliest stages of human ontogenesis. To serve in this capacity, these cells must …

The development of the visual system involves the coordination of spatial and temporal
events to specify the organization of varied cell types, including the elongation of axons from …

It is widely accepted that the process of retinal cell fate determination is under tight
transcriptional control mediated by a combinatorial code of transcription factors. However …

Context-specific integration of information received from the Notch, Transforming growth
factor β, Wingless/Wnt, Hedgehog and Epidermal growth factor receptor signaling pathways …

Retinal organoids are three-dimensional structures derived from human pluripotent stem
cells (hPSCs) which recapitulate the spatial and temporal differentiation of the retina, serving …

In humans, haploinsufficiency of either SOX2 or PAX6 is associated with microphthalmia,
anophthalmia or aniridia. In this study, through the genetic spatiotemporal specific ablation …

Human eye development is coordinated through an extensive network of genetic signalling
pathways. Disruption of key regulatory genes in the early stages of eye development can …