Simple Summary Cellular senescence consists of a permanent block of cell proliferation in
the presence of an active metabolism. It is a physiological process occurring when cells …

Cellular senescence has emerged as a potent tumor suppression mechanism that restrains
proliferation of cells at risk for malignant transformation. Although senescent cells have …

Cellular senescence is a state of durable cell arrest that has been identified both in vitro and
in vivo. It is associated with profound changes in gene expression and a specific secretory …

Cancer is a devastating disease that increases exponentially with age. Cancer arises from
cells that proliferate in an unregulated manner, an attribute that is countered by cellular …

Several cancer interventions induce DNA damage and promote senescence in cancer and
nonmalignant cells. Senescent cells secrete a collection of proinflammatory factors …

Senescent cells are found to accumulate in aged individuals, as well as in cancer patients
that receive chemotherapeutic treatment. Although originally believed to halt cancer …

Cellular senescence in cancer development is known to have tumor‐suppressive and tumor‐
promoting roles. Recent studies have revealed numerous molecular mechanisms of …

Cellular senescence is an established tumour-suppressive mechanism that prevents the
proliferation of premalignant cells. However, several lines of evidence show that senescent …

Senescence is a double-edged sword that can function in opposite directions. It is a
potential mechanism for a cell to avoid malignant transformation. However, senescence can …

The senescence‐associated secretory phenotype (SASP), where senescent cells produce a
variety of secreted proteins including inflammatory cytokines, chemokines, matrix …