The promise of circulating tumor DNA (ctDNA) in the management of early-stage colon cancer: a critical review

S Chakrabarti, H Xie, R Urrutia, A Mahipal - Cancers, 2020 - mdpi.com
Simple Summary Currently, the treatment for localized colon cancer consists of surgery and,
if the presence of residual cancer cells is suspected, chemotherapy following the surgery …

Circulating tumor DNA (ctDNA) in adjuvant therapy of early stage colon cancer: current status and future perspectives

C Merk, A Martling, J Lindberg, L Benhaim… - Acta …, 2022 - Taylor & Francis
Background This article reviews the current knowledge on circulating tumor DNA (ctDNA) in
early stage colon cancer and ongoing trials on ctDNA-guided treatment in the adjuvant …

Circulating tumor DNA in early-stage colon cancer: ready for prime time or needing refinement?

JP Solar Vasconcelos, M Boutin… - … Advances in Medical …, 2022 - journals.sagepub.com
Liquid biopsies are the detection of molecular information in fluids from patients with cancer.
In colorectal cancer (CRC), the most promising liquid biopsy strategy is the use of circulating …

Cell-free circulating (tumor) DNA before surgery as a prognostic factor in non-metastatic colorectal cancer: a systematic review

SJ Schraa, KL van Rooijen, M Koopman, GR Vink… - Cancers, 2022 - mdpi.com
Simple Summary Patients with colorectal cancer without distant metastases are often cured
by surgical tumor resection. Follow-up is needed because of the risk of disease recurrence …

The future of ctDNA-Defined minimal residual disease: personalizing adjuvant therapy in colorectal cancer

A Bent, S Raghavan, A Dasari, S Kopetz - Clinical colorectal cancer, 2022 - Elsevier
Our understanding of the diagnostic and prognostic use of circulating tumor DNA (ctDNA) in
colorectal cancer (CRC) has broadly expanded over the past few years. The utilization of …

Circulating tumor DNA as a minimal residual disease assessment and recurrence risk in patients undergoing curative-intent resection with or without adjuvant …

A Chidharla, E Rapoport, K Agarwal, S Madala… - International journal of …, 2023 - mdpi.com
Emerging data have suggested that circulating tumor DNA (ctDNA) can be a reliable
biomarker for minimal residual disease (MRD) in CRC patients. Recent studies have shown …

Minimal Residual Disease--Directed Adjuvant Therapy for Patients With Early-Stage Colon Cancer: CIRCULATE-US.

IH Sahin, Y Lin, G Yothers, PC Lucas… - Oncology …, 2022 - search.ebscohost.com
BACKGROUND: The ability to detect circulating tumor DNA (ctDNA), a novel surrogate for
minimal residual disease (MRD) for patients with solid tumors, has significantly evolved over …

Circulating tumor DNA analysis detects minimal residual disease and predicts recurrence in patients with stage II colon cancer

J Tie, Y Wang, C Tomasetti, L Li, S Springer… - Science translational …, 2016 - science.org
Detection of circulating tumor DNA (ctDNA) after resection of stage II colon cancer may
identify patients at the highest risk of recurrence and help inform adjuvant treatment …

ctDNA applications and integration in colorectal cancer: an NCI Colon and Rectal–Anal Task Forces whitepaper

A Dasari, VK Morris, CJ Allegra, C Atreya… - Nature reviews Clinical …, 2020 - nature.com
An increasing number of studies are describing potential uses of circulating tumour DNA
(ctDNA) in the care of patients with colorectal cancer. Owing to this rapidly developing area …

ctDNA and adjuvant therapy for colorectal cancer: time to re-invent our treatment paradigm

M Naidoo, P Gibbs, J Tie - Cancers, 2021 - mdpi.com
Simple Summary There is currently a lack of useful tests to detect microscopic residual
disease in patients who have undergone surgery to remove their bowel cancer. This inability …