Since the pioneering work of the early 1900s, the lens has been used as a model system for
the study of tissue development in vertebrates. A number of embryological transplantation …

Lens-cell differentiation occurs at a fairly early stage of embryogenesis and results in very
simple tissue architecture. These features allow the embryonic lens to provide a paradigm of …

Ocular lens development represents an advantageous system in which to study regulatory
mechanisms governing cell fate decisions, extracellular signaling, cell and tissue …

For more than a century, the lens has provided a relatively simple structure in which to study
developmental mechanisms. Lens induction, where adjacent tissues signal the cell fate …

Recent studies demonstrated a number of links between chromatin structure, gene
expression, extracellular signaling and cellular differentiation during lens development …

Lens development is a stepwise process accompanied by the sequential activation of
transcription factors. Transcription factor genes can be classified into three groups according …

The ocular lens is a model system for understanding important aspects of embryonic
development, such as cell specification and the spatiotemporally controlled formation of a …

Several stages in the lens determination process have been defined, though it is not known
which gene products control these events. At mid-gastrula stages in Xenopus, ectoderm is …

Activation of the first lens-specific gene of the chicken, δ 1-crystallin, is dependent on a
group of lens nuclear factors, δEF2, interacting with the δ 1-crystallin minimal enhancer …

Embryologists at the turn of the century discovered the process of embryonic induction while
investigating the mechanisms of lens determination. The simple view of lens induction from …